PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
High-risk human papillomavirus (HPV) E7 proteins allow oncogenic transformation of HPV-infected cells by inactivating host mobile proteins. High-risk however not low-risk HPV E7 goal PTPN14 for proteolytic degradation, suggesting that PTPN14 degradation could also be associated to their oncogenic exercise. HPV infects human keratinocytes however the function of PTPN14 in keratinocytes and the implications of PTPN14 degradation are unknown....