SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
Background: Mortalin/GRP-75/mt-hsp70 is a mitochondrial chaperone protein, discovered in the cytoplasm, endoplasmic reticulum and cytoplasmic vesicles. It features in many mobile processes similar to mitochondrial biogenesis, intramobile trafficking, cell proliferation, signaling, immortalization and tumorigenesis. Thus, inhibition of mortalin is a promising avenue for cancer remedy. Previous research in our lab...