TFR2 Rabbit Polyclonal Antibody

Description: A polyclonal antibody for detection of TFR2 from Human, Mouse, Rat. This TFR2 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human TFR2 protein

Description: Available in various conjugation types.

Description: Available in various conjugation types.

Description: Unconjugated

Description: Unconjugated

Description: Unconjugated

Description: Unconjugated

Description: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Description: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand| the heditary hemochromatosis protein HFE| competes for binding with transferrin for an overlapping C-terminal binding site.|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.|miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.|miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis| pregnancy| irritable bowel syndrome and in HIV patients.|PTM:N- and O-glycosylated| phosphorylated and palmitoylated. The serum form is only glycosylated.|PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.|PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).|Belongs to the peptidase M28 family. M28B subfamily.|Contains 1 PA (protease associated) domain.|subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen| DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.|

Description: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand| the heditary hemochromatosis protein HFE| competes for binding with transferrin for an overlapping C-terminal binding site.|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.|miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.|miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis| pregnancy| irritable bowel syndrome and in HIV patients.|PTM:N- and O-glycosylated| phosphorylated and palmitoylated. The serum form is only glycosylated.|PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.|PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).|Belongs to the peptidase M28 family. M28B subfamily.|Contains 1 PA (protease associated) domain.|subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen| DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.|

Description: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand| the heditary hemochromatosis protein HFE| competes for binding with transferrin for an overlapping C-terminal binding site.|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.|miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.|miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis| pregnancy| irritable bowel syndrome and in HIV patients.|PTM:N- and O-glycosylated| phosphorylated and palmitoylated. The serum form is only glycosylated.|PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.|PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).|Belongs to the peptidase M28 family. M28B subfamily.|Contains 1 PA (protease associated) domain.|subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen| DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.|

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TFR2 (C-term). This antibody is tested and proven to work in the following applications:

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2)

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Transferrin Receptor 2 (TFR2). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Transferrin Receptor 2 (TFR2). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human, Mouse Transferrin Receptor 2 (TFR2). This antibody is labeled with PE.