Telomerase is a ribonucleoprotein ribonucleic enzyme that’s important for mobile immortalization by way of elongation of telomere repeat sequences on the finish of chromosomes. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase holoenzyme, is a key regulator of telomerase exercise. Telomerase exercise, which has been detected within the majority of most cancers cells, is accompanied by… Continue reading
SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
Background: Mortalin/GRP-75/mt-hsp70 is a mitochondrial chaperone protein, discovered in the cytoplasm, endoplasmic reticulum and cytoplasmic vesicles. It features in many mobile processes similar to mitochondrial biogenesis, intramobile trafficking, cell proliferation, signaling, immortalization and tumorigenesis. Thus, inhibition of mortalin is a promising avenue for cancer remedy. Previous research in our lab have recommended that mortalin contributes to breast cancer improvement and development.… Continue reading
Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells round small epithelial-lined areas. Due to the rarity of adenomyoepitheliomas, the molecular knowledge describing them are restricted. Adenomyoepitheliomas are thought-about to be benign or have low malignant potential, and be susceptible to native recurrence. Malignant transformation has been related to homozygous deletion of CDKN2A or somatic… Continue reading
Cellular immortalization and lentiviral infection: from fibroblasts to hepatocytes in hepatic damage caused by drugs
This week we will talk about the transformation of human fibroblasts into hepatocytes using the biotechnological techniques: infection with lentiviral vectors and cellular immortalization. The purpose? Study a situation with a high idiosyncratic component: the damage that causes the liver of each person and the consumption of medicines. The authors? The Experimental Hepatología Unit of… Continue reading
Viruses: chameleon beings, from villains to good guys
With the arrival of winter, concerns about the transmission of several viruses, especially the flu, increase. When people think of viruses, they quickly associate them with diseases or chemical weapons. However, for us, biotechnologists, they can also be important tools, as we can use their ability to infiltrate and exploit living systems in favor of… Continue reading
Respiratory virus detection methods
There are many methods consist on the identifcation of the repiratory virus. Viral respiratory infection can be caused by nemerous viruses: RSV A and RSV B (Respiratory Syncytial Virus). Parainfluenza Virus (types 1–4). Numerous Adenoviruses. Rhinoviruses. metapneumovirus. Bocavirus. Avian Influenza Virus (H5N1 and H7N9). Coronaviruses; including SARS (Severe Acute Respiratory Virus) and SARS-COV2 (The novel… Continue reading