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Category: Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.

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Response of breast cancer carcinoma spheroids to combination therapy with radiation

Posted on October 27, 2020 by Frank

Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: Growth arrest with no change in α/β ratio   Agents that enhance tumor radiosensitivity are of curiosity in enhancing outcomes in radiotherapy (XRT). DNA-PK inhibitors lead to radiosensitization and in addition to alterations in cell adhesion proteins. We investigated the combination of… Continue reading

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Vitamin D and its Effects on DNA Methylation in Development, Aging and Disease

Posted on October 27, 2020 by Frank

Vitamin D and its Effects on DNA Methylation in Development, Aging and Disease  DNA methylation is more and more being recognised as a mechanism by means of which environmental exposures confer illness threat. Several research have examined the affiliation between vitamin D and modifications in DNA methylation in areas as various as human and animal improvement, genomic… Continue reading

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DNA damage and health effects in juvenile haddock

Posted on October 27, 2020 by Frank

DNA injury and health effects in juvenile haddock (Melanogrammus aeglefinus) uncovered to PAHs related to oil-polluted sediment or produced water  The analysis goal was to review the presence of DNA damages in haddock uncovered to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from completely different sources: 1) extracts of oil produced water (PW), dominated by 2-ring PAHs;… Continue reading

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Role of H1 and DNA methylation in selective regulation of transposable parts

Posted on October 27, 2020 by Frank

Role of H1 and DNA methylation in selective regulation of transposable parts throughout warmth stress   Heat harassed Arabidopsis crops launch heterochromatin-associated transposable factor (TE) silencing, which nevertheless will not be accompanied by main reductions of epigenetic repressive modifications. In this research, we explored the practical function of histone H1 in repressing heterochromatic TEs in response to… Continue reading

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Maximized quantitative phosphoproteomics allows high confidence

Posted on October 27, 2020 by Frank

Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA harm signaling community   The upkeep of genomic stability depends on DNA harm sensor kinases that detect DNA lesions and phosphorylate an in depth community of substrates. The Mec1/ATR kinase is without doubt one of the major sensor kinases answerable for orchestrating DNA harm responses. Despite the… Continue reading

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Revelation of point mutations effect in Mycobacterium tuberculosis

Posted on October 27, 2020 by Frank

Revelation of point mutations effect in Mycobacterium tuberculosis MfpA protein that concerned in mycobacterial DNA supercoiling and fluoroquinolone resistance   MfpA protein encoded by Mycobacterium tuberculosis (Mtb) and stands for Mycobacterium fluoroquinolone resistance protein A. This protein gives Mtb intrinsic resistant property from fluoroquinolone antibiotics by inhibiting DNA gyrase which can be recognized to be the first… Continue reading

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.

Posted on May 10, 2020May 10, 2020 by Frank

Long-lived species Homo sapiens have advanced strong safety mechanisms towards most cancers by repressing telomerase and sustaining brief telomeres, thereby delaying the onset of the majority of most cancers varieties till post-reproductive age. Indeed, telomerase is silent in most differentiated human cells, predominantly on account of the transcriptional repression of its catalytic element telomerase reverse… Continue reading

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  • Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.
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Recent Posts

  • Compare antibodies lab reagents for research
  • Compare polyclonal lab reagents for research
  • Assay Lab Reagents for Research
  • TEST Lab Reagents for Research
  • Advances on human amniotic epithelial cells and its clinical application potential

RSS Trends in Genetics

  • When cleaning facilitates cluttering – genome editing in ciliates
  • Repetitive elements in aging and neurodegeneration
  • Maternal plastid inheritance: two abating factors identified
  • Future of DNA-based insect monitoring
  • Start of life controlled by poly(A) tail-mediated remodeling
  • ATRX, a guardian of chromatin
  • Fluctuating selection and the determinants of genetic variation
  • The genetic architecture of behavioral canalization
  • The gut microbiota links disease to human genome evolution
  • miRNA biogenesis and inherited disorders: clinico-molecular insights

Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • DNA
  • Establishment and characterization of HBV-associated B lymphocytes with an immortalization potential.
  • GMO
  • Goat
  • Green
  • Guinea
  • Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
  • Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.
  • Pig
  • Pigeon
  • PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
  • Plant
  • plasmid
  • Plate
  • PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
  • RNA
  • SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.

Recent Posts

  • Compare antibodies lab reagents for research
  • Compare polyclonal lab reagents for research
  • Assay Lab Reagents for Research
  • TEST Lab Reagents for Research
  • Advances on human amniotic epithelial cells and its clinical application potential
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