Skip to content

CelltaGen

셀타젠 Genetic Genotyping

Menu
  • Home
  • RNA
  • Assay
  • DNA
  • Plant
  • Guinea
  • Distributors
Menu
Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.

Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.

Posted on May 10, 2020May 10, 2020 by Frank

Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells round small epithelial-lined areas. Due to the rarity of adenomyoepitheliomas, the molecular knowledge describing them are restricted. Adenomyoepitheliomas are thought-about to be benign or have low malignant potential, and be susceptible to native recurrence.

Malignant transformation has been related to homozygous deletion of CDKN2A or somatic mutations in TERT, however stays unexplained in many circumstances.

Here, we describe a case of carcinomatous transformation of each epithelial and myoepithelial cells in an estrogen receptor-negative adenomyoepithelioma triggered by amplification of MYC.

Break-apart fluorescence in situ hybridization revealed a rise in the MYC gene copy quantity (3-Four copies/cell in 37%, > Four copies/cell in 40%). Deregulation of MYC is accountable for uncontrolled proliferation and cellularimmortalization in basal-like breast cancers.

Our case demonstrates that genomic instability occasions related to gene amplification could also be concerned in the carcinogenesis of malignant adenomyoepitheliomas.

Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.

Mitochondrial dynamics and metabolism in induced pluripotency.

Somatic cells will be reprogrammed to pluripotency by both ectopic expression of outlined components or publicity to chemical cocktails.

During reprogramming, somatic cells endure dramatic modifications in a wide selection of mobile processes, equivalent to metabolism, mitochondrial morphology and performance, cell signaling pathways or immortalization. Regulation of these processes throughout cell reprograming lead to the acquisition of a pluripotent state, which permits indefinite propagation by symmetrical self-renewal with out dropping the power of reprogrammed cells to differentiate into all cell varieties of the grownup.

In this evaluation, latest knowledge from totally different laboratories displaying how these processes are managed throughout the phenotypic transformation of a somatic cell into a pluripotent stem cell will likely be mentioned.

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • NCBI References of Lab polyclonals
  • Suppliers of Lab recombinants
  • Distributors of Lab monoclonals
  • Compare monoclonal lab reagents for research
  • Compare Pcr lab reagents for research

RSS Trends in Genetics

  • Advancing GWAS of human communication
  • Invigorating ELSI: reflexive approaches to enhance policy development
  • Toward equitable biomarkers of aging: rethinking methylation clocks
  • Selfish B chromosome evades genome elimination
  • Protist genomics: key to understanding eukaryotic evolution
  • Architectural RNAs: blueprints for functional membraneless organelle assembly
  • Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification
  • Investigating RNA dynamics from single molecule transcriptomes
  • Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
  • Spatial omics enters the microscopic realm: opportunities and challenges

Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • DNA
  • Establishment and characterization of HBV-associated B lymphocytes with an immortalization potential.
  • GMO
  • Goat
  • Green
  • Guinea
  • Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
  • Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.
  • Pig
  • Pigeon
  • PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
  • Plant
  • plasmid
  • Plate
  • PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
  • RNA
  • SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.

Recent Posts

  • NCBI References of Lab polyclonals
  • Suppliers of Lab recombinants
  • Distributors of Lab monoclonals
  • Compare monoclonal lab reagents for research
  • Compare Pcr lab reagents for research

RSS Trends in Genetics

  • Advancing GWAS of human communication
  • Invigorating ELSI: reflexive approaches to enhance policy development
  • Toward equitable biomarkers of aging: rethinking methylation clocks
  • Selfish B chromosome evades genome elimination
  • Protist genomics: key to understanding eukaryotic evolution
  • Architectural RNAs: blueprints for functional membraneless organelle assembly
  • Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification
  • Investigating RNA dynamics from single molecule transcriptomes
  • Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
  • Spatial omics enters the microscopic realm: opportunities and challenges

Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • DNA
  • Establishment and characterization of HBV-associated B lymphocytes with an immortalization potential.
  • GMO
  • Goat
  • Green
  • Guinea
  • Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
  • Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.
  • Pig
  • Pigeon
  • PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
  • Plant
  • plasmid
  • Plate
  • PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
  • RNA
  • SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.

Recent Posts

  • NCBI References of Lab polyclonals
  • Suppliers of Lab recombinants
  • Distributors of Lab monoclonals
  • Compare monoclonal lab reagents for research
  • Compare Pcr lab reagents for research
© 2025 CelltaGen | Powered by Superbs Personal Blog theme